Runjie Yuan, UNC Lineberger Comprehensive Cancer Center In this study, researchers will visualize the changes in cell mechanics, adhesion, and spreading of lung cancer cell lines as a consequence of exosome treatment to identify the role of exosomes in modulating cellular behavior in the tumor microenvironment. Tejeshwar Rao, University of Alabama at Birmingham The ultimate goal of the study is to use the hTERT MSC exosomes as controls for characterizing and developing adipose-derived mesenchymal stem cell-derived exosomes for therapy. In this innovative study, ATCC hTERT MSC exosomes will be used in a modified T cell immunosuppression assay to evaluate the immunomodulatory potential of the exosomes. If successful, the results of this study will aid in the development of therapies that stimulate a tumor-specific immune response that could benefit patients with reduced T cell function.
In this study, researchers will work toward finding novel treatments for colorectal cancer by establishing cGMP-grade extracellular vesicles from the HCT 116 colorectal cancer cell line. Subree Subramanian PhD, EV Therapeutics, Inc. In this innovative study, the group will examine if treatment of neuronal cells with hTERT MSC exosomes will lead to the inhibition of virus replication, thus potentially protecting cortical neurons from death. In previous research, the team has demonstrated that Zika virus infection kills primary cultures of cortical neuronal cells at days 3-5 post infection. The EVs will help the growth of stem cells, and if successful, the animals will show an increase in the number of mature cells in various tissues, thus enabling researchers to carry out various cancer and infectious disease studies. These innovative experiments are designed to regulate the stem cells in mice using extracellular vesicles. They hypothesize that cancer cells can reverse to normal differentiated cells when using extracellular vesicles post irradiation.įarhang Alem and Fatah Kashanchi, George Mason University In this innovative research, the scientists plan to examine the rate of repair when extracellular vesicles (MSC or iPSC) are added to irradiated cancer cells. Lance Liotta and Fatah Kashanchi, George Mason University
They will utilize repair assays in 2-D and 3-D cultures post DNA damage or autophagy inhibitor treatment and will look for cancer cell development over a long period of time to determine if cancer extracellular vesicles not only perform immediate repair but also contribute to cancer development. In this study, researchers will compare side-by-side the repair effects of cancer versus normal extracellular vesicles in cancer development.
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